Chunk #52 — Methods — SNP heritability

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Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.

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h2SNP of PTSD was estimated using LDSC. LD scores calculated within KGP3 European populations (https://data.broadinstitute.org/alkesgroup/LDSCORE/) were used for the input. Analyses were limited to HapMap 3 SNPs, with the MHC region excluded (chr6: 26–34 million base pairs). SNP-based heritability was also calculated as partitioned across 28 functional annotation categories (https://data.broadinstitute.org/alkesgroup/LDSCORE/) using stratified LDSC97.