the Caucasian, Asian and African samples to determine the two major ancestral GABRG1 haplotypes (H1 and H3 + H4 as shown in Figure 5) and created the haplotype specific sequences from NCBI refGene’s GABRG1 transcript (NM_173536.3). We ran Mfold 3.2 (Zuker et al, 1999) with the haplotype specific transcript sequences and computed ten different foldings for each haplotype. There were no significant differences in the folding energy between the two ancestral haplotypes (p = 0.187).
