On average, a RefSeq TSS was associated with 4.9 enhancers and an enhancer with 2.4 TSSs and we observed different regulatory architectures around genes (Supplementary Fig. 30). For example, at the beta-globin locus the CAGE expression patterns of four locus control region hypersensitive sites are highly correlated (Pearson's r between 0.88 and 0.98) with the expression of known target genes23,24 HBG2, HBD, and to some extent HBG1.
