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Chunk #6 — Introduction

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Changes in gene expression in regions of the extended amygdala of alcohol-preferring rats after binge-like alcohol drinking.
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rats (Kimpel et al., 2007). Previously, it was established that P rats, given one-hour access to 10% ethanol 4 times during the dark cycle (water available ad lib), will consume nearly as much alcohol as rats given 24-hr free-choice access to 10% ethanol (Murphy et al., 1986). Another study (Bell et al., 2005) demonstrated that if 15 and 30% ethanol were concurrently available during the multiple 1-hr sessions (water available ad lib), then ethanol intakes of 1.5–2.0 g/kg/session were obtained by P rats, which produced BACs in the range of 100 mg%. This paradigm qualifies as a ‘binge-like’ alcohol-drinking model, since drinking occurred within a 1-hr time frame and produced BACs over 80 mg%.