Chunk #14 — RESULTS — Analysis of the TSAICG Cohort Replicates Association of De Novo Likely Gene-Disrupting Variants

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De Novo Coding Variants Are Strongly Associated with Tourette Disorder.

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This analysis replicates the association of de novo LGD variants with TD (RR 1.97, 95% CI 1.03–3.68, p = 0.04, one-sided rate ratio test; Figure 3A; Table 2). Again, neither synonymous de novo variants (RR 1.10, 95% CI 0.81–1.47, p = 0.3) nor de novo in-frame indels (RR 1.67, 95% CI 0.22–8.97, p = 0.4) showed any differences between TD and controls.