The relevant information for the subjects in the current study has been reported [63]. Briefly, samples from the 10,038 participants in the Korea Association Resource (KARE) Project were obtained in two recruiting areas, Ansung and Ansan, in South Korea. Participant ages ranged from 40 to 69 years. Genomic DNA was available for 10,004 participants and was genotyped with the Affymetrix Genome-Wide Human SNP Array 5.0. Genotypes were called with Bayesian Robust Linear Modeling using the Mahalanobis Distance (BRLMM) algorithm. Those samples with low call rates (N = 401), contamination (N = 11), sex inconsistencies (N = 41), cryptic relatedness (N = 608), or serious concomitant illness (N = 101) were removed. After all the samples had been filtered with this standard quality control procedure [63], 8,842 individual samples remained for the current study (4,183 males and 4,659 females).
