The research design and procedures were reviewed and approved by the University of California Institutional Review Board. Informed, written assent from the adolescent subject and consent from one parent were obtained for each subject before data collection. Study staff reviewed the study procedures with eligible individuals, as well as with the person’s parent/legal guardian. Initial discussion regarding study requirements took place over the telephone. At this time study procedures, including saliva and urine collection, survey administration, and expectations for the outpatient hospital stay (participant must refrain from smoking, must remain in the hospital unit, etc.) were clarified. Finally, any questions the participant or the parent/legal guardian had were answered and a baseline appointment was set up. On the day of the baseline appointment, all study procedures were reviewed again, additional questions answered, and all consent/assent forms signed.
