between sensation seeking and neuroanatomical differences in frontocingulate thickness and surface area, volume of basal ganglia structures (e.g., nucleus accumbens and globus pallidus), 13 , 14 and reward‐cued connectivity of frontostriatal pathways, 15 , 16 highlighting many of the same regions and circuits associated with the described binge/intoxication stage. As some of these observed differences extend beyond hypothesised subcortical regions used to characterize sensation seeking as a ‘bottom‐up’ process and clearly implicate relevant cortical features, 13 , 17 , 18 cortical neuroimaging phenotypes (e.g., regional volume, thickness, and surface area), including phenotypes assessing cortical–subcortical connections, may help to explain relations between sensation seeking and alcohol use phenotypes at the neurobiological level.
