behavioral, psychosocial, socioeconomic and neighborhood, and microorganismic factors, which may limit the feasibility and applicability of ERS. Instead, we treated important determinants of lipid outcomes such as age, sex, race/ethnicity, education (an indicator of socioeconomic factor), body mass index (BMI), and selected dietary nutrients as covariates and confounding factors. The methodology can of course be generalized when the agnostic search for important predictors is expanded to a broader set of exposures capturing personal and community environment.