can imagine that the additional layer of trying to find common environmental measures that have been assessed across studies to incorporate gene–environment interaction into these efforts becomes formidable. I often hear social scientists chiding geneticists for “ignoring” the environment; hopefully the reader will now have better appreciation of the daunting challenges that are being faced by geneticists and why incorporating environmental information into gene finding efforts is yet another layer of complexity on an already challenging problem. Of course one could argue that taking into account environmental information might increase the effect size associated with any one locus and reduce the number of participants that are required, but this debate is beyond the scope of this paper. The take home message is that a degree of patience and appreciation for the challenges faced by each respective field is critical, as social scientists begin to enter the world of genetics, and geneticists try to incorporate aspects of social science.
