To provide a framework for appropriate future replication, we examined whether this interaction would be captured when using other definitions of abuse. All analyses were conducted only in MOAFTS. (a) Childhood sexual abuse was associated with increased likelihood of reporting anhedonia [O.R. 2.41, 95% C.I. 1.52–3.83], but the interaction with rs1049353 was not significant [OR = 0.56, 95% C.I. 0.23–1.43]. (b) We modified our childhood physical abuse measure to include physical punishment such as sometimes/often being slapped by a parent. Not only did the association between abuse and anhedonia attenuate [O.R. 1.47, 95% C.I. 1.08–2.01] but the interaction was no longer significant [OR =0.86, 95% C.I. 0.46–1.62]. (c) An interaction with a dichotomous measures of adult exposure to adult (assaultive or non-assaultive) traumas was also not significant [OR=0.49, 95% C.I. 0.23–1.05]. This series of analyses indicate that replication analyses are likely to be successful only when examining childhood physical abuse.
