Like many complex central nervous system (CNS) disorders, the roles of neuropathology, environment and trauma in BP are largely unknown; there are reports of ventricular enlargement, gray matter, hippocampal and cerebellar hypoplasia, and anomalies of white matter tracts,18, 19, 20, 21 that are nonspecific and inconsistent. There is also evidence of abnormal neuronal cell migration22 and of altered adult neurogenesis.23,24 Because viable brain tissue is unavailable, and there is no well-defined genetic event or neuropathology, there are simply no good neural models to study BP.
