Moreover, we employed three parameters to examine the regional nodal properties in 90 brain regions. We identified 21 global hubs with higher values in either regional nodal parameter that play a vital role in the global information integration between different parts of the network. The global hubs were predominately located in the prefrontal and parietal lobes, providing a potential explanation for their well-documented activation by many cognitive functions [3], [48]. The global hubs identified in this study have also been recognized as global hubs by previous studies on structural and functional brain networks [10], [11], [37], [52], [61], [62], [63], [64], [65]. Interestingly, several global hubs (bilateral SFGmed and left PCUN) have been recently indicated as the core of a rich-club organization, playing a central role in information integration and in conferring robustness to its structural core [66].
