We report the results of a combined GWAMA of depression continuum including MDD (18,759 cases and controls) and depressive symptoms (51,258 participants). In the discovery stage, we found genome-wide significant associations in the FHIT and PLEK2 genes. One SNP in the intron of the FHIT gene showed a significant association in the combined analysis of discovery and replication samples of MDD and depressive symptoms samples, and exceeded a genome-wide significance threshold.
