The reduction in mean χ2 and genomic inflation factor suggested some loss of power to detect SNP effects. Down-sampling decreased the power by 17.8 pp to detect the median of squared standardized coefficients among the genome-wide significant SNPs (i.e., median r2 = 0.0038%), and about 5–45 pp less power to detect the three assumed effect-size magnitudes (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}^{2}=$$\end{document}r2= 0.003%, 0.004%, or 0.005%) (Figures S2, 3). Therefore, we recommend that users interested in following up on individual genome-wide significant SNPs associated with externalizing prioritize the version with 23andMe data.
