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Chunk #42 — DISCUSSION

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Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression.
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effect size and only observable in limited situations. Our lack of replication coincides with findings of the Christchurch Health and Developmental Study,67 a prospective longitudinal birth-cohort, with measures, outcomes, and sample (both size and origin on the south island of New Zealand) nearly identical to the original report. This lack of evidence for a strong, robust effect should be taken into account before planning future research on this topic.