Chunk #19 — Results — Sprague-Dawley rats voluntarily consume 20% ethanol using the intermittent-access two-bottle choice drinking paradigm

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Varenicline, a partial agonist at neuronal nicotinic acetylcholine receptors, reduces nicotine-induced increases in 20% ethanol operant self-administration in Sprague-Dawley rats.

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The amount of ethanol consumed after 30 minutes significantly correlated with the blood ethanol concentrations (BECs) measured in both the 20% ethanol intermittent group, r2=0.7607, p<0.001 (Fig 1B) and in the 10% ethanol continuous group, r2=0.6782, p<0.05 (Figure 1C). The BECs were much higher in animals consuming 20% ethanol with a range between 6 to 122 mg/dl in comparison to the 10% continuous ethanol consuming animals (10 to 48 mg/dl).