The findings should be considered in light of seven caveats. First, the sample consists of offspring from high risk, densely AUD-affected families, and as such findings may not be generalizable to a less selected sample. Second, although all data across multiple waves of assessment were included in the analyses, some participants have not passed through the period of risk, and thus some individuals who may eventually develop AUD or an AUD problem are treated here as unaffected and censored at their last assessment. However, survival analyses appropriately account for these censored data. Third, the interview data do not provide details about timing and duration of offspring exposure to parental AUD in their rearing environment. Fourth, the severity of parental AUD and its persistence have not been taken into account in the analyses. It is not clear whether the effects observed for parental AUD would differ if severity, duration, and/or remission of parental AUD were considered. Fifth, our data reflect risk factors for transitions without consideration of potentially inhibitory/protective influences. Sixth, effects of maternal AUD may reflect in part in utero
