The read count Kij for gene i in sample j is described with a GLM of the negative binomial family with a logarithmic link: (1)\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document} $$ \begin{aligned} K_{ij} & \sim \text{NB}(\text{mean} = \mu_{ij}, \text{dispersion} = \alpha_{i}) \\ \mu_{ij} &= s_{ij} q_{ij} \\ \end{aligned} $$ \end{document}Kij∼NB(mean=μij,dispersion=αi)μij=sijqij
