In the MH, one-way ANOVA revealed a significant effect of the Group on the POMC mRNA level [F(2,21) = 3.53, p<0.05] (Fig. 4A). Newman-Keuls post hoc tests showed that the POMC mRNA levels in both the H-RI and L-RI rats were significantly lower than that of NR group (p<0.05).