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Chunk #21 — Results — Relationship of polygenic risk for alcohol dependence to cognitive function

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Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort.
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Previous epidemiological studies have found a positive association between alcohol consumption and cognitive ability (Britton, Singh‐Manoux & Marmot 2004; Corley et al. 2011) and this was replicated in GS:SFHS (Supporting Information Table S2). The proportion of variance in cognitive test scores explained by PGRS is shown in Fig. 1 (less than 0.2 percent in all cases), where only measures of cognitive ability that are significantly associated with both SAGE and Yale‐Penn PGRS are presented.