The imprinted region on 7q32 consists of maternally expressed genes (CPA4 and KLF14) flanking paternally expressed genes (MEST, MESTIT1) (Figure 3). The T2D associated marker rs4731702 is located 14 kb from the maternally expressed KLF14 transcription factor21 and only increases risk of T2D when carried on the maternal chromosome. The basal cell carcinoma variant rs157935, conferring risk through the paternal allele, is located 170 kb telomeric to the imprinted region.
