Our PubMed search identified 81 articles published since 2008. From these, we selected three comprehensive meta-analyses that covered multiple medications and were published in the past 5 years.10–12 We also selected meta-analyses of 7 individual medications13–18 and 2 RCTs of medications to treat AUD, a multi-center RCT20 and a single-site RCT.21 To estimate the frequency of adverse events, we selected 4 meta-analyses,14,15,22,23 and 3 multi-center RCTs.23–25
