LD structure, researchers should use this information to genotype markers that capture genetic variation across the gene of interest, not limit their study to a single marker or polymorphism (except in strongly justified situations, such as where previous studies that have done exhaustive genotyping consistently implicate a particular marker or region of the gene). If a researcher is interested in understanding whether a particular gene is involved in a given outcome, (s)he should do a thorough job of characterizing the genetic variation across that gene. However, issues associated with multiple testing will need to be considered when analyzing the data, as discussed below.
