transmission and synaptogenesis in the adult CNS108, and, more important to this review, in the regulation of multiple aspects (e.g., neuronal proliferation, migration, differentiation, survival, and synaptogenesis) of prenatal CNS development109. The early and widespread distribution of cannabinoid receptors in the fetal and neonatal brain, at levels that appear to exceed those seen in the adult CNS110, and the important physiological role that CB1 receptors play in GABA-driven cortical network activity111, raises concern regarding potential effects of prenatal marijuana exposure on fetal and subsequent brain development.
