Random effects analysis of these contrast images in a priori regions of interest (ROI) employed a Group(2) × Odor(2) × Condition(2) random effects, linear mixed model analysis of variance in SPSS 17.0 for Windows (SPSS Inc., Chicago, IL). “Group” represents the two heavy drinking groups who differ in family history, “Odor” refers to effects from AO and ApCO (each contrasted against the odorless control events), while “Condition” indicates alcohol and placebo infusion. We concentrated analyses on AO and ApCO, which represent two classes of appetitive stimuli. As alcohol can prime desire to both drink and eat (e.g., Caton, Bate, & Hetherington, 2007; De Wit, 1996; Yeomans, Hails, & Nesic, 1999) NApO (odors that represent stimuli that are not ingested) were reserved to determine if alcohol altered the olfactory sensory response in primary olfactory cortex.
