The landscape of psychiatric genetics has changed dramatically since the endophenotype concept was most recently reintroduced in the literature. The field has moved towards large, collaborative gene finding research networks for psychiatric outcomes (such as the Psychiatric Genomics Consortium) that have sample sizes in the tens of thousands, moving away from an endophenotype strategy with its emphasis on heritability. However, the trade-off between large-scale genotyping, where amassing very large samples often comes at the cost of less precise measures, and the study of endophenotypes, which may require deeper, more costly measurement on a smaller number of subjects, is currently unknown.
