Chunk #17 — Introduction — Rationale for the present study: Mechanisms of Alzheimer’s disease identified as upstream regulators of alcohol-sensitive protein networks in C57BL/6J mice
In addition to their importance in Alzheimer’s disease, these proteins regulate critical molecular and cellular functions in the brain. IPA Core Analysis showed that the alcohol-sensitive protein clusters play important roles in energy metabolism and homeostasis (ATP5D, HK1, AK1, PGAM1, CKB), cytoskeletal development and function (BASP1, CAP1, DPYSL2 [CRMP2], ALDOA, TUBA1A, CFL2, ACTG1), cell signaling and endocytosis (STXB1[MUNC-18], ALDOA, AMPH, CPLX2, CLTA), cellular/oxidative stress (HSPA5, HSPA8, ENO1, ENO2), transcription and DNA regulation (PURA, YWHAZ). While we did not find direct overlap between the significantly changed proteins in the mPFC and AMY, similar protein families emerged, including the heat shock proteins, proteins involved in the SNARE complex, and enolase proteins suggested related mechanisms of action between brain regions.
