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Chunk #33 — RESULTS — Gene Expression Profiling of hESCs, iPSCs, and Cells Differentiated from Them

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Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions.
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the expression levels of four markers representative of NSCs in iPSC- and hESC-derived NSC populations. No significant difference was observed among the lines. Of the 20 genes associated with dopaminergic/neuronal specification, differentiation, and maturation, or PD listed in Table 2, many of them including EN1, Nurr1, TH, AADC, and Girk2 were upregulated in dopaminergic populations derived from both the iPSCs and hESCs. Nevertheless, differences in expression of some genes among the lines were observed. These include SNCA, NGFR, MAOB, MAOA, TFAP2A, and COMT.