rs3800373, rs1360780 and rs9470080), a gene that codes for a `chaperone' protein that regulates GR sensitivity, were found to interact with the severity of childhood abuse in the prediction of PTSD symptoms in adults44. Another study demonstrated an association between genetic variation in FKBP5 and inefficient recovery of HPA axis activity after the Trier Social Stress Test in healthy participants, identifying a potential risk factor for chronically elevated cortisol levels and ultimately stress-related psychopathology45.
