to a diminished ovarian estradiol output 27. Thus, the delay of puberty caused by Aza treatment is not due to either deregulation of PRL secretion or corticosterone hypersecretion. Altogether, these results suggest that inhibition of DNA methylation delays puberty by unleashing a repressive mechanism that, operating within the neuroendocrine brain, keeps puberty in check by inhibiting genes (such as Kiss1) required for puberty to occur.
