A large number of studies have investigated the P300 in schizophrenia. Meta-analysis of these studies confirms that P300 amplitude reductions and latency delays occur in schizophrenia more than in controls (Bramon et al. 2005); furthermore P300 phenotypes are heritable (van Beijsterveldt & van Baal, 2002). P300 phenotypes satisfy the criteria for an endophenotype of schizophrenia.
