A total of 10 EHR-based cohorts (not including the MVP, which also contributed data) provided GWAS summary statistics. These cohorts consisted of four US-based sites (Vanderbilt University Medical Center’s BioVu, the Mass General Brigham Biobank, Mount Sinai’s BioMe, and Mayo Clinic’s MayoGC) and six non-US sites (iPSYCH from Denmark, FinnGen, HUNT Study from Norway, STR-STAGE from Sweden, UK Biobank, and Estonia Biobank). More details on procedures at each site are provided in the Supplementary Note. At each site, a broad definition of PTSD cases was defined based on patients having at least 1 PTSD or other stress disorder code (see Supplementary Note for the list of corresponding ICD-9 and 10 codes). All other patients without such a code were defined as controls. From a total of 817,181 participants across all cohorts, this case definition resulted in 78,687 cases based on the broad definition (9.6%).
