All of these signals were subjected to visual inspection of cluster plots, and in all cases (with one exception noted below) nearby correlated SNPs also showed a strong signal (see signal plots). Thus, genotyping artefacts are unlikely to be responsible for these associations. Indeed, at the time of writing, 12 of these 25 strong signals represent replications of previously reported findings (only those with extensive prior replication are reported in Table 2). Of the remainder, follow-up studies (reported elsewhere) have confirmed all but one of the loci (ten in total) for which replication has been attempted10,19-24. The other replication study gave equivocal results. Of the 18 loci implicated in autoimmune disease, 5 show associations (P<0.001) to more than 1 condition, leading to a number of further potential new associations, at least one of which has also been replicated10.
