Our results suggest that the focus of endophenotypic theory and research should change, moving away from gene finding to using the results of gene finding to understand psychophysiological mechanisms of etiological relevance to psychopathology. As Braff (2014, this issue) notes in his commentary, the value of these MTFS endophenotype papers may best be realized in what comes next with projects that combine the study of molecular genetics, endophenotypes, and psychiatric disorder, such as COGS. As we and others continue to expand our work, we must actively seek to share data readily, rapidly, and unconditionally with other researchers, preferably without embargo. Open science and open consents may not always be practical or appropriate but should be pursued to the fullest extent possible. It is our hope that this special issue provides a foundation for such cooperation, informing future steps in endophenotype genetics that enable a more satisfying answer than Mr. Rumsfeld's about what is known and what is not.
