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Chunk #1 — Introduction

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The effect of alcohol on the differential expression of cluster of differentiation 14 gene, associated pathways, and genetic network.
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condition which can affect inflammation of the liver, intestines, lungs, and brain [5]. Alcohol consumption affects inflammatory processes through its effect to suppress the production of inflammatory mediators. It also compromises the integrity of the lining of the gastrointestinal tract and lungs, causes defects in granulocytes, inhibits their function, and impairs the antigen-presenting factor of dendritic cells [1]. While most immunosuppression associated with alcohol consumption does not cause significant effects, it does leave the body more susceptible to secondary immune insults. For example, lung inflammation and interleukin-18-mediated neutrophil infiltration after burn injury in rats are increased by acute alcohol intoxication [6].