The proportion of D-variants likewise influences the power. Under the Recessive-Set model, both the CAST and the CMC methods perform well when a reasonably high proportion of the variants contribute to disease-risk, whereas both the variant-by-variant and the CAST method are unable to identify disease-groups under the other scenarios (Figure 4). On the other hand, the weighted-sum method is generally robust to a low proportion of D-variants in the group, but a higher proportion of D-variants yields higher power (Figure 4).
