lower than that for an EA population. Martin et al. (2017) studied transferability of PRSs constructed based on single-ancestry GWASs to other ancestries, and demonstrated that scores inferred from EA GWASs may perform poorly in other ancestries. Others have recently shown that PRSs are highly associated with genetic ancestry and cautioned against using EA-based PRSs in diverse populations (Reisberg et al., 2017; Curtis, 2018). Collectively, these studies highlight the need to adapt PRS construction methods to diverse ancestries. Even across Hispanic/Latino populations, LD patterns and allele frequencies can differ. For example, at rs4133185, a SNP on chromosome 17, we see both different allele frequencies (Burkart et al., 2018) and distinct LD patterns (see Figures S1-S6 in the Supplementary Methods) across multiple background groups with distinct admixture histories in HCHS/SOL.
