Families were recruited for genetic studies of pediatric psychopathology at the Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD at Massachusetts General Hospital. Screening and recruitment for some subjects (N= 121) occurred prior to the publication of DSM-IV. Initial affection status for those subjects was based on DSM-IIIR criteria but lifetime DSM-IV-TR criteria was asked at follow up, and only those subjects endorsing a life-time DSM-IV-TR diagnosis of ADHD were enrolled. Remaining subjects were screened and assessed according to DSM-IV-TR criteria (N=188). Psychiatric assessments were made with K-SADSE (Epidemiologic Version). We conducted direct interviews with subjects older than 12 years of age and indirect interviews with their mothers (i.e., mothers complete the structured interview about their offspring) for all subjects and combined data from direct and indirect interviews by considering a diagnostic criterion positive if it was endorsed in either interview. A committee of board-certified child and adult psychiatrists or psychologists who were blind to the subject’s ADHD status, referral source and all other data resolved diagnostic uncertainties. Diagnoses presented for review were considered positive only when the
