proteasomal mediated degradation. This process releases and activates NF-κB which now translocates to the nucleus. The activation of alternative pathway, which is commonly associated with RelB results in regulated processing of the p100 precursor protein to p52 and subsequent translocation of p52-RelB heterodimers to the nucleus[18]. Although NF-κB activation occurs mainly through canonical and non-canonical pathways, during the past decade a number of pathways for NF-κB activation has been elucidated (Fig 1).
