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Chunk #0 — Introduction

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Glucocorticoid Receptor (NR3C1) Gene Polymorphism Moderate Intervention Effects on the Developmental Trajectory of African-American Adolescent Alcohol Abuse.
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Alcohol and other drug use during adolescence remains a major public health issue. Adolescent alcohol use, particularly when initiated at an early age and abuse (e.g., binge drinking, drunkenness), is strongly associated with a wide variety of problems and adverse outcomes in late adolescence and young adulthood, such as driving under the influence, suicidal ideation, risky sexual behavior, substance use disorder, and antisocial behavior (Duncan et al. 1997; Newcomb and Bentler 1988). Globally, alcohol use and related problems (e.g., injury and disease) bring tremendous societal costs and economic burden (Rehm et al. 2009). Therefore, effective and early interventions with long-term effects are needed to prevent adolescent alcohol use.