All participants were adults. Contributing studies provided individual-level genotype data or summary statistics consistent with their institutional review board-approved protocols. Descriptions of each of the 11 contributing studies are provided in the Supplementary Information. In many cohorts included in the consortium, all the controls were trauma exposed (for example, Nurses Health Study II PTSD substudy). Thus, in the combined analysis, the vast majority of controls were trauma exposed (N controls=15 548, N trauma-exposed controls=13 638, 87.7% of controls were trauma exposed). Case and control numbers along with other data set information is provided in Supplementary Table S1, and Figure 1 illustrates the study and analytical design.
