loci contributing to biological differences between BIP and SCZ and found polygenic risk score associations with specific symptom dimensions (Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium, 2018). A complete picture of cross-phenotype genetic relationships will require understanding both same and opposite directional effects. In addition, to the extent that pleiotropic loci may reveal targets for drug discovery, opposite directional effects on psychiatric disorders could help anticipate problematic off-target effects.
