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Chunk #37 — Discussion

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Resting state EEG power and coherence abnormalities in bipolar disorder and schizophrenia.
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First, increased beta power at high frequencies was found in BP relative to SZ. In terms of EEG signatures of network activation, several studies have converged on the finding that beta power positively correlates with activity in the DMN (Hlinka et al., Laufs et al., 2003; Mantini et al., 2008). Given the association between the DMN and mind wandering (Christoff et al., 2009; Kirschner et al., 2011; Mason et al., 2007), this may suggest that BP more frequently attend to internal thoughts. In terms of the functional interpretation, beta power may index the detection of novel stimuli (Brenner et al. 2009; Kopell et al. 2011). Interestingly, novel stimuli induce significantly more activation in the parietal region (Arbabshirani et al. 2012), and this region also shows greater synchronous activity with the DMN found in BP relative to SZ and NC (Ongür et al. 2010). Given this pair of results, the robust increase in beta power at rest observed in our study may indicate that BP are more responsive to novel stimuli in the environment, an effect that corresponds to recent findings