Only very few of the tools dedicated to enrichment analysis have offered continuous and up-to-date service after their initial release. g:Profiler has remained vital since its first publication in the 2007 NAR web server issue, and has published update articles in 2011 and 2016 (8,15,16). In order to continuously support researchers from a variety of different scientific domains, we have increased the number of supported species and gene identifier types, while keeping the data update frequency, programmable access and core high quality data sources in steady manner throughout the years (Figure 1). As the complexity and size of the underlying data has been growing we have now introduced a complete technical rewrite of the g:Profiler. This allows us to serve our users faster and more conveniently through modern user interface and programming interfaces as well as opens up new avenues for adding features and maintaining the stable service.
