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Chunk #40 — RESULTS — SMALL SAMPLE SIZE WITH LARGE EFFECTS

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A comparison of approaches to account for uncertainty in analysis of imputed genotypes.
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Here, the advantage of applying mixture models is apparent, with average power gains of 10–12%. The contrast is greater at lower imputation accuracies (top row of Fig. 3) and is maintained even when we applied the incorrect additive regression model to data simulated with a strong dominant effect (Fig. 3B) (i.e. the green solid line is well above the blue dotted line at modest accuracies).