In this meta-analysis of 21 Stage 1 discovery GWAS cohorts followed by targeted Stage 2 replication of 25 loci in 33 additional cohorts (totaling up to 122,743 non-diabetic participants), we report the novel genome-wide significant associations of SNPs in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and FAM148B with FG and one SNP near IGF1 with FI and HOMA-IR. We have also confirmed associations of variants in GCK, GCKR, G6PC2 and MTNR1B with FG, and achieved genome-wide significance for the recently reported DGKB/TMEM195 locus24 and for variants in the known T2D-associated TCF7L2 and SLC30A8. All of the FG-associated SNPs demonstrate consistent nominal associations with HOMA-B; and those in GCK, G6PC2, MTNR1B, DGKB/TMEM195, ADCY5, FADS1 and GLIS3 do so at genome-wide significant levels. As previously reported11,12,30, GCKR is also associated with FI and HOMA-IR.
