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Chunk #8 — I. The genetic epidemiology of FTO — The FTO locus - a cluster of BMI-associated SNPs in FTO’s first intron

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The bigger picture of FTO: the first GWAS-identified obesity gene.
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Taken together, the BMI-associated FTO region, initially identified in European ancestry population, has been narrowed down through taking advantage of a weaker correlation between SNPs in African ancestry populations. These insights will help focus further efforts needed to pinpoint the causal variant(s).