paperKB
coga / coga-kb
Help
Sign in

Chunk #50 — Online Methods — Generate data-driven covariance matrices Uk.

Source
Flexible statistical methods for estimating and testing effects in genomic studies with multiple conditions.
Embedded
yes

Text

Next, we fit a mixture of MVN distributions to these strongest effects using methods from Bovy et al.35. Bovy et al. describe an EM algorithm for fitting a model similar to eqs. 2 and 3, with the crucial difference that there are no scaling parameters on the covariances: (5)p(bj | π, U)=∑k=1KπkNR(bj;0,Uk).