Using these ethnic-specific per allele odds ratio estimates and the aggregate risk allele counts, we built a quantitative risk model to compare the distribution of genetic risks between populations associated with these marker alleles. The higher average number of risk alleles in African Americans caused their distribution to be slightly right shifted (towards higher log ORs) compared to European Americans, however their relatively smaller per allele odds ratio resulted in wide overlap with the European American distribution (Figure 2). The Japanese Americans had a wider distribution of risk because of the large per allele odds ratio, but the low average risk allele counts caused the Japanese distribution to be left-shifted (towards lower log ORs) compared to European Americans. The distributions for Latinos and Native Hawaiians were very similar to the European Americans.
